Protein Details: Potassium voltage-gated channel subfamily H member 1
Protein ID
ICDB_Pro_1052
Protein Name
Potassium voltage-gated channel subfamily H member 1
Gene Name
Kcnh1; Eag
Organism
Rattus norvegicus (Rat)
Length
962 amino acids
AlphaFoldDB
AF-Q63472-F1-model_v4.pdb
Function
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel . Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation; in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity)
Sequence
Ligand Binding
Binding Site
Disease
Location
Detected in cerebellum; at parallel fiber synapses on Purkinje cell spines (PubMed:25556795). Detected in hippocampus neurons (at protein level) (PubMed:24495567). Detected in brain; but not in the other tissues tested; expression is highest in granular cells of the dentate gyrus; in hippocampus CA3 pyramidal cells; and in cerebellar granule cells (PubMed:7925287). Detected in pituitary (PubMed:10718922).
DOI ID
10.1002/j.1460-2075.1994.tb06767.x; 10.1093/emboj/16.21.6337; 10.1074/jbc.273.36.23080; 10.1046/j.1365-2826.2000.00447.x; 10.1016/j.febslet.2012.07.055; 10.1074/jbc.m112.372540; 10.1186/1471-2202-15-23; 10.1113/jphysiol.2014.281600; 10.1126/science.aaf8070
RefSeq
NP_113930.1; XP_006250553.1